兔抗DNAJC2多克隆抗体

Background:

This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described.

Applications:

ELISA, IHC

Name of antibody:

DNAJC2

Immunogen:

Synthetic peptide of human DNAJC2

Full name:

DnaJ heat shock protein family (Hsp40) member C2

Synonyms:

ZRF1; ZUO1; MPP11; MPHOSPH11

SwissProt:

Q99543

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colorectal cancer and human ovarian cancer

IHC Recommend dilution:

30-150