兔抗DAND5多克隆抗体

Background:

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry.

Applications:

ELISA, IHC

Name of antibody:

DAND5

Immunogen:

Full length fusion protein

Full name:

DAN domain family member 5, BMP antagonist

Synonyms：

SP1; CER2; COCO; CRL2; CERL2; DANTE; GREM3; CKTSF1B3

SwissProt:

Q8N907

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human esophagus cancer

IHC Recommend dilution:

25-100