兔抗CHRDL2多克隆抗体

Background:

CHRDL2 (chordin-related protein 2), also known as BNF1 (breast tumor novel factor 1) or CHL2 (chordin-like 2), is a 429 amino acid protein that belongs to the chordin family of proteins. CHRDL2 contains three VWFC (von Willebrand Factor type C) domains and is predominantly expressed in uterus and moderately expressed in prostate, liver, ovary, heart and testis. Due to alternative splicing events, CHRDL2 exists as five isoforms, namely isoform I, isoform II, isoform VII, isoform VIII and isoform IX. Two of these isoforms are secreted, while the other three localize to the cytoplasm. Functioning as a BMP-binding inhibitor, CHRDL2 directly interacts with BMPs and blocks their binding to BMP receptors, thereby inhibiting BMP activity. In breast, lung and colon tumors, CHRDL2 expression is upregulated, suggesting a possible role in tumorigenesis.

Applications:

ELISA, IHC

Name of antibody:

CHRDL2

Immunogen:

Synthetic peptide of human CHRDL2

Full name:

chordin-like 2

Synonyms：

BNF1; CHL2; FKSG37

SwissProt:

Q6WN34

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human liver cancer and Human cervical cancer

IHC Recommend dilution:

25-100