兔抗TFEB多克隆抗体

Background:

Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937).

Applications:

ELISA, IHC

Name of antibody:

TFEB

Immunogen:

Fusion protein of human TFEB

Full name:

transcription factor EB

Synonyms:

TCFEB; BHLHE35; ALPHATFEB

SwissProt:

P19484

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human tonsil and Human gastric cancer

IHC Recommend dilution:

50-200