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Background: |
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene. |
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Applications: |
WB, IF |
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Name of antibody: |
TBL1X |
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Immunogen: |
Fusion protein of human TBL1X |
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Full name: |
transducin beta like 1X-linked |
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Synonyms: |
EBI; TBL1; SMAP55 |
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SwissProt: |
O60907 |
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WB Predicted band size: |
62 kDa |
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WB Positive control: |
SW480 cell lysate |
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WB Recommended dilution: |
1000-5000 |
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IF positive control: |
Hela cells |
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IF Recommend dilution: |
50-100 |
