小鼠抗TBL1X单克隆抗体

Background:

The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene.

Applications:

WB, IF

Name of antibody:

TBL1X

Immunogen:

Fusion protein of human TBL1X

Full name:

transducin beta like 1X-linked

Synonyms:

EBI; TBL1; SMAP55

SwissProt:

O60907

WB Predicted band size:

62 kDa

WB Positive control:

SW480 cell lysate

WB Recommended dilution:

1000-5000

IF positive control:

Hela cells

IF Recommend dilution:

50-100