兔抗CSK多克隆抗体

Background:

Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.

Applications:

WB, IF

Name of antibody:

CSK

Immunogen:

Synthesized peptide derived from internal of human CSK.

Full name:

c-src tyrosine kinase

Synonyms：

0

SwissProt:

P41240

WB Predicted band size:

51 kDa

WB Positive control:

Jurkat cells lysate

WB Recommended dilution:

500-3000

IF positive control:

A549 cells

IF Recommend dilution:

100-500