兔抗KLHL12多克隆抗体

Background:

This gene encodes a member of the KLHL (Kelch-like) family of proteins. This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis. This protein may act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex to promote substrate-specific ubiquitylation. Ubiquitylation by this complex has been shown to regulate the Wnt signaling pathway as well as COPII vesicle coat size. A pseudogene has been identified on chromosome 22. Alternative splicing results in multiple transcript variants.

Applications:

ELISA, IHC

Name of antibody:

KLHL12

Immunogen:

Fusion protein of human KLHL12

Full name:

kelch like family member 12

Synonyms:

DKIR; C3IP1

SwissProt:

Q53G59

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human esophagus cancer

IHC Recommend dilution:

20-100