兔抗NPR1多克隆抗体

Background:

Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms . The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).

Applications:

ELISA, IHC

Name of antibody:

NPR1

Immunogen:

Synthetic peptide of human NPR1

Full name:

Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)

Synonyms：

ANPa, NPRA, ANPRA, GUC2A, GUCY3A

SwissProt:

P16066

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human brain and Human gastric cancer

IHC Recommend dilution:

25-100