小鼠抗ACVRL1单克隆抗体

Background:

This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.

Applications:

WB

Name of antibody:

ACVRL1

Immunogen:

Fusion protein of human ACVRL1

Full name:

activin A receptor like type 1

Synonyms:

HHT; ALK1; HHT2; ORW2; SKR3; ALK-1; TSR-I; ACVRLK1

SwissProt:

P37023

WB Predicted band size:

56 KD

WB Positive control:

Jurkat, MCF7, K562 and Hela cell lysates

WB Recommended dilution:

500-2000