小鼠抗TAF12单克隆抗体

Background:

Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I. Two transcript variants encoding the same protein have been found for this gene.

Applications:

ELISA, WB

Name of antibody:

TAF12

Immunogen:

Fusion protein of human TAF12

Full name:

TATA-box binding protein associated factor 12

Synonyms:

TAF2J; TAFII20

SwissProt:

Q16514

WB Predicted band size:

18 kDa

WB Positive control:

HeLa whole cell lysate

WB Recommended dilution:

1000-5000