兔抗FOXO1(Phospho-Ser319)多克隆抗体

Background:

FKHR belongs to the forkhead family of transcription factors, which are characterized by a distinct forkhead domain. It may play a role in myogenic growth and differentiation. The mammalian DAF-16-like transcription factors, FKHR, FKHRL1, and AFX, function as key regulators of insulin signaling, cell cycle progression, and apoptosis downstream of phosphoinositide 3-kinase. Gene activation through binding to insulin response sequences has been essential for mediating these functions. D-type Cyclins (in Class III) is required for FKHR mediated inhibition of cell cycle progression and transformation. FKHR gene is mapped to chromosome 13q14

Applications:

WB, IHC, IF

Name of antibody:

FOXO1 (Phospho-Ser319)

Immunogen:

Synthetic peptide of human FOXO1 (Phospho-Ser319)

Full name:

forkhead box O1 (Phospho-Ser319)

Synonyms：

FKH1; FKHR; FOXO1A

SwissProt:

Q12778

IHC positive control:

Human breast carcinoma

IHC Recommend dilution:

50-100

WB Predicted band size:

70 kDa

WB Positive control:

NIH/3T3 cells untreated or treated with serum starvation

WB Recommended dilution:

500-1000

IF Positive control:

Hela cells

IF Recommended dilution

100-200