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021-54845833/15800441009
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Background: |
FKHR belongs to the forkhead family of transcription factors, which are characterized by a distinct forkhead domain. It may play a role in myogenic growth and differentiation. The mammalian DAF-16-like transcription factors, FKHR, FKHRL1, and AFX, function as key regulators of insulin signaling, cell cycle progression, and apoptosis downstream of phosphoinositide 3-kinase. Gene activation through binding to insulin response sequences has been essential for mediating these functions. D-type Cyclins (in Class III) is required for FKHR mediated inhibition of cell cycle progression and transformation. FKHR gene is mapped to chromosome 13q14 |
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Applications: |
WB, IHC, IF |
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Name of antibody: |
FOXO1 (Phospho-Ser319) |
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Immunogen: |
Synthetic peptide of human FOXO1 (Phospho-Ser319) |
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Full name: |
forkhead box O1 (Phospho-Ser319) |
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Synonyms： |
FKH1; FKHR; FOXO1A |
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SwissProt: |
Q12778 |
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IHC positive control: |
Human breast carcinoma |
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IHC Recommend dilution: |
50-100 |
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WB Predicted band size: |
70 kDa |
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WB Positive control: |
NIH/3T3 cells untreated or treated with serum starvation |
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WB Recommended dilution: |
500-1000 |
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IF Positive control: |
Hela cells |
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IF Recommended dilution |
100-200 |
