小鼠抗SKIL单克隆抗体

Background:

The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

Applications:

WB, IHC

Name of antibody:

SKIL

Immunogen:

Fusion protein of human SKIL

Full name:

SKI-like proto-oncogene (SKIL), transcript variant 1

Synonyms:

SNO; SnoA; SnoI; SnoN

SwissProt:

P12757

IHC positive control:

human colon tissue and human liver tissue; adenocarcinoma of human ovary tissue and adenocarcinoma of human endometrium tissue

IHC Recommend dilution:

30-150

WB Predicted band size:

77 kDa

WB Positive control:

HepG2, Hela, SVT2, A549, COS7, Jurkat, MDCK, PC12, MCF-7 cell lysates

WB Recommended dilution:

500-2000