兔抗FGFR3多克隆抗体

Background:

This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.

Applications:

ELISA, IHC

Name of antibody:

FGFR3

Immunogen:

Synthetic peptide of human FGFR3

Full name:

Fibroblast growth factor receptor 3

Synonyms：

ACH, CEK2, JTK4, CD333, HSFGFR3EX

SwissProt:

P22607

ELISA Recommended dilution:

500-5000

IHC positive control:

Human liver cancer

IHC Recommend dilution:

25-100