兔抗RPS6KA5(Phospho-Ser212) 多克隆抗体

Background:

Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).

Applications:

WB

Name of antibody:

RPS6KA5(Phospho-Ser212)

Immunogen:

Peptide sequence around phosphorylation site of serine 212 (A-Y-S(p)-F-C) derived from Human MSK1.

Full name:

ribosomal protein S6 kinase, 90kDa, polypeptide 5

Synonyms：

MSK1; RLPK; MSPK1

SwissProt:

O75582

WB Predicted band size:

90 kDa

WB Positive control:

NIH/3T3 cells lysates treated with EGF

WB Recommended dilution:

500-1000