小鼠抗PTPN1单克隆抗体

Background:

The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. [provided by RefSeq].

Applications:

WB, IHC, IF, FC

Name of antibody:

PTPN1

Immunogen:

Fusion protein of human PTPN1

Full name:

protein tyrosine phosphatase, non-receptor type 1 (PTPN1), transcript variant 1

Synonyms:

PTP1B

SwissProt:

P18031

IHC positive control:

human colon tissue and human lymph node tissue

IHC Recommend dilution:

30-150

WB Predicted band size:

50 kDa

WB Positive control:

HepG2, Hela, COS7, Jurkat, MDCK, PC12, MCF-7 cell lysates

WB Recommended dilution:

200-1000