兔抗ZNF281多克隆抗体

Background:

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF281, also known as GC-box-binding zinc finger protein 1, ZBP-99 or ZNP-99 (zinc finger DNA-binding protein 99), is a zinc finger protein that belongs to the Krüppel C2H2-type zinc finger protein family. It is expressed ubiquitously at low levels with predominant expression in kidney, liver, lymphocytes and placenta. ZNF281 localizes to the nucleus and contains four C2H2-type zinc fingers. ZNF281 plays a role in repressing the transcription of a variety of genes including Gastrin and ODC (ornithine decarboxylase). In particular, ZNF281 functions by binding to the G-rich box in the enhancer region of the gene. Upon DNA damage, ZNF281 may become phosphorylated by Atm or ATR.

Applications:

ELISA, WB, IHC

Name of antibody:

ZNF281

Immunogen:

Fusion protein of human ZNF281

Full name:

zinc finger protein 281

Synonyms：

ZBP-99; ZNP-99

SwissProt:

Q9Y2X9

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human thyroid cancer and human brain

IHC Recommend dilution:

60-450

WB Predicted band size:

97 kDa

WB Positive control:

A549 cell

WB Recommended dilution:

500-2000