兔抗LDLR多克隆抗体

Background:

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.

Applications:

ELISA, IHC

Name of antibody:

LDLR

Immunogen:

Synthetic peptide of human LDLR

Full name:

low density lipoprotein receptor

Synonyms:

FH; FHC; LDLCQ2

SwissProt:

P01130

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer and human brain

IHC Recommend dilution:

25-100