兔抗LAMTOR1多克隆抗体

Background:

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.

Applications:

ELISA, IHC

Name of antibody:

LAMTOR1

Immunogen:

Synthetic peptide of human LAMTOR1

Full name:

late endosomal/lysosomal adaptor, MAPK and MTOR activator 1

Synonyms:

p18; PDRO; C11orf59; p27RF-Rho; Ragulator1

SwissProt:

Q6IAA8

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human tonsil

IHC Recommend dilution:

20-100