兔抗BHLHA15多克隆抗体

Background:

MIST1 (muscle, intestine and stomach expression 1), also known as BHLHB8 (basic helix-loop-helix domain containing, class B, 8), is a 189 amino acid nuclear protein expressed in liver, brain, skeletal muscle and spleen. MIST1 contains a basic helix-loop-helix (bHLH) domain and belongs to the bHLH family of transcription factors. Members of this family bind to the E-box motifs present in the promoter or enhancer regions of a variety of developmentally regulated genes and function as either transcriptional activators or transcriptional repressors. MIST1 is capable of binding to E-box motifs as a homodimer or a heterodimer with E-proteins (E12 and E47) and is believed to play a role regulating the transcriptional activity of MyoD, a protein involved in the regulation of muscle cell development. More specifically, MIST1 functions as a repressor of MyoD activity, ensuring that myoblast populations do not differentiate. In addition, MIST1 is expressed in mammary epithelial cells and is essential for the regulation of mammary gland development.

Applications:

ELISA, WB, IHC

Name of antibody:

BHLHA15

Immunogen:

Synthetic peptide of human BHLHA15

Full name:

basic helix-loop-helix family member a15

Synonyms:

MIST1; BHLHB8

SwissProt:

Q7RTS1

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colorectal cancer

IHC Recommend dilution:

20-100

WB Predicted band size:

21 kDa

WB Positive control:

Human muscle tissue，Human spleen tissue，Mouse Pancreas tissue，Human pancreas tissue and Mouse liver tissue lysates

WB Recommended dilution:

200-1000