小鼠抗AKAP12单克隆抗体

Background:

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Applications:

WB, IHC

Name of antibody:

AKAP12

Immunogen:

Fusion protein of human AKAP12

Full name:

A-kinase anchoring protein 12

Synonyms:

SSeCKS; AKAP250

SwissProt:

Q02952

IHC positive control:

Human spleen tissue and Human testicle tissue; Human adult heart tissue

IHC Recommend dilution:

200-500

WB Predicted band size:

191 KD

WB Positive control:

U251 and Hela cell lysates

WB Recommended dilution:

500-2000