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021-54845833/15800441009
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Background: |
CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1,278 amino acid protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
CYFIP2 |
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Immunogen: |
Fusion protein of human CYFIP2 |
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Full name: |
cytoplasmic FMR1 interacting protein 2 |
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Synonyms： |
PIR121 |
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SwissProt: |
Q96F07 |
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ELISA Recommended dilution: |
2000-5000 |
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IHC positive control: |
Human liver cancer and human gastric cancer |
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IHC Recommend dilution: |
50-200 |
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WB Predicted band size: |
148 kDa |
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WB Positive control: |
Mouse brain and human fetal brain tissue |
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WB Recommended dilution: |
500-2000 |
