兔抗HIRA多克隆抗体

Background:

This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.

Applications:

ELISA, IHC

Name of antibody:

HIRA

Immunogen:

Synthetic peptide of human HIRA

Full name:

histone cell cycle regulator

Synonyms：

TUP1; DGCR1; TUPLE1

SwissProt:

P54198

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human brain

IHC Recommend dilution:

20-100