兔抗CSF1R(Phospho-Tyr561) 多克隆抗体

Background:

Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development.

Applications:

WB, IHC

Name of antibody:

CSF1R(Phospho-Tyr561)

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 561 (N-S-Y(p)-T-F) derived from Human CSFR .

Full name:

colony stimulating factor 1 receptor

Synonyms：

FMS; CSFR; FIM2; HDLS; C-FMS; CD115; CSF-1R; M-CSF-R

SwissProt:

P07333

IHC positive control:

Human brain tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

108 kDa

WB Positive control:

HepG2 cells lysates treated with PMA

WB Recommended dilution:

500-1000