小鼠抗MYC单克隆抗体

Background:

c-Myc is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.

Applications:

WB, IHC, IF

Name of antibody:

MYC

Immunogen:

Fusion protein of human MYC

Full name:

v-myc avian myelocytomatosis viral oncogene homolog (MYC)

Synonyms:

bHLHe39; c-Myc; MRTL; MYCC

SwissProt:

P01106

IHC positive control:

human breast tissue and human liver tissue; carcinoma of human pancreas tissue and human thyroid tissue

IHC Recommend dilution:

10-50

WB Predicted band size:

49 kDa

WB Positive control:

Hela cell lysate

WB Recommended dilution:

1000-5000