兔抗CBL多克隆抗体

Background:

This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder

Applications:

ELISA, WB

Name of antibody:

CBL

Immunogen:

Synthetic peptide of human CBL

Full name:

Cbl proto-oncogene, E3 ubiquitin protein ligase

Synonyms：

CBL2; NSLL; C-CBL; RNF55; FRA11B

SwissProt:

P22681

ELISA Recommended dilution:

2000-5000

WB Predicted band size:

100 kDa

WB Positive control:

231 cells

WB Recommended dilution:

500-2000