兔抗BLNK多克隆抗体

Background:

This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

BLNK

Immunogen:

Fusion protein of human BLNK

Full name:

B-cell linker

Synonyms:

bca; AGM4; BASH; LY57; SLP65; BLNK-S; SLP-65

SwissProt:

Q8WV28

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer and human gastric cancer

IHC Recommend dilution:

50-300