小鼠抗GCLC单克隆抗体

Background:

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct

Applications:

WB, IHC

Name of antibody:

GCLC

Immunogen:

Fusion protein of human GCLC

Full name:

glutamate-cysteine ligase, catalytic subunit (GCLC), transcript variant 1

Synonyms:

GCL; GCS; GLCL; GLCLC

SwissProt:

P48506

IHC positive control:

human pancreas tissue and carcinoma of human thyroid tissue

IHC Recommend dilution:

30-150

WB Predicted band size:

73 kDa

WB Positive control:

HepG2, A549, COS7, Jurkat, PC12, MCF-7 cell lysates

WB Recommended dilution:

200-1000