小鼠抗NANP单克隆抗体

Background:

Sialic acids are a family of 9-carbon 2-keto-3-deoxy sugars that are found on the ends of glycoproteins and glycolipids and play important roles in recognition events within the cell. Playing an important role in cell-cell and protein-protein recognition, N-acetylneuraminate is the main form of sialic acid in vertebrates. NANP (N-acylneuraminate-9-phosphatase), also known as HDHD4 (Haloacid dehalogenase-like hydrolase domain-containing protein 4), is a 248 amino acid protein that belongs to the haloacid dehalogenase (HAD) family and is responsible for dephosphorylating Neu5Ac-9-phosphate to form N-acetylneuraminate. Characteristic of the HAD phosphatase family, the catalytic activity of NANP is dependent upon the presence of magnesium and is inhibited by vanadate and calcium.

Applications:

WB, IHC

Name of antibody:

NANP

Immunogen:

Fusion protein of human NANP

Full name:

N-acetylneuraminic acid phosphatase (NANP)

Synonyms:

C20orf147; dJ694B14.3; HDHD4

SwissProt:

Q8TBE9

IHC positive control:

human prostate tissue

IHC Recommend dilution:

30-150

WB Predicted band size:

28 kDa

WB Positive control:

Jurkat cell lysate

WB Recommended dilution:

500-2000