小鼠抗CASP4单克隆抗体

Background:

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].

Applications:

WB

Name of antibody:

CASP4

Immunogen:

Fusion protein of human CASP4

Full name:

caspase 4, apoptosis-related cysteine peptidase (CASP4), transcript variant gamma

Synonyms:

ICE(rel)II; ICEREL-II; ICH-2; Mih1/TX; TX

SwissProt:

P49662

WB Predicted band size:

43 kDa

WB Positive control:

HepG2, Hela, SVT2, A549, COS7, Jurkat, MDCK and MCF7 cell lysates

WB Recommended dilution:

1000-5000