兔抗ANGPTL4多克隆抗体

Background:

This gene is a member of the angiopoietin/angiopoietin-like gene family and encodes a glycosylated, secreted protein with a fibrinogen C-terminal domain. This gene is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. The encoded protein is a serum hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. The encoded protein may play a role in several cancers and it also has been shown to prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. Decreased expression of this protein has been associated with type 2 diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4.

Applications:

ELISA, IHC

Name of antibody:

ANGPTL4

Immunogen:

Fusion protein of human ANGPTL4

Full name:

Angiopoietin-related protein 4

Synonyms：

NL2, ARP4, FIAF, PGAR, HFARP, pp1158, ANGPTL2

SwissProt:

Q9BY76

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human cervical cancer and human esophagus cancer

IHC Recommend dilution:

25-100