小鼠抗CA12单克隆抗体

Background:

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].

Applications:

WB, IHC

Name of antibody:

CA12

Immunogen:

Fusion protein of human CA12

Full name:

carbonic anhydrase XII (CA12), transcript variant 1

Synonyms:

CAXII; HsT18816

SwissProt:

O43570

IHC positive control:

human pancreas tissue and human colon tissue; human kidney tissue and carcinoma of human kidney tissue

IHC Recommend dilution:

30-150

WB Predicted band size:

39 kDa

WB Positive control:

A549 cell lysate

WB Recommended dilution:

500-2000