兔抗CERS6多克隆抗体

Background:

The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1, LASS2, LASS3, LASS4, LASS5 and LASS6) and they all are involved in sphingolipid synthesis. LASS6 is a widely expressed 384 amino acid endoplasmic reticulum, multi-pass membrane protein. On the luminal side of the endoplasmic reticulum membrane, the N-terminal asparagine residue is glycosylated. In cells deficient for CLN9, LASS6 corrects growth and apoptosis, and increases the levels of short ceramide species, such as C14:0- and C16:0-ceramides.

Applications:

ELISA, IHC

Name of antibody:

CERS6

Immunogen:

Synthetic peptide of human CERS6

Full name:

ceramide synthase 6

Synonyms：

CERS5; LASS6

SwissProt:

Q6ZMG9

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human ovarian cancer and Human brain

IHC Recommend dilution:

50-200