兔抗ELOB多克隆抗体

Background:

This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, Aug 2008]

Applications:

ELISA, IHC

Name of antibody:

ELOB

Immunogen:

Fusion protein of human ELOB

Full name:

elongin B

Synonyms:

SIII; TCEB2

SwissProt:

Q15370

IHC positive control:

Human colorectal cancer

IHC Recommend dilution:

30-150