兔抗CDC6多克隆抗体

Background:

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.

Applications:

ELISA, WB, IHC

Name of antibody:

CDC6

Immunogen:

Synthetic peptide of human CDC6

Full name:

cell division cycle 6

Synonyms:

CDC18L; HsCDC6; MGORS5; HsCDC18

SwissProt:

Q99741

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human breast cancer and Human colon cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

63 kDa

WB Positive control:

K562 and 293T cells

WB Recommended dilution:

200-1000