兔抗DMRT3多克隆抗体

Background:

The DMRT (doublesex and mab-3 related transcription factor) genes encode a large family of transcription factors that are related to the Drosophila doublesex proteins. Expressed primarily in the gonads, DMRT proteins contain cysteine-rich DNA-binding motifs and are thought to play an important role in sexual development. DMRT3 (doublesex and mab-3 related transcription factor 3), also known as DMRTA3, is a 472 amino acid protein that contains one DM DNA-binding domain and belongs to the DMRT family. Localized to the nucleus, DMRT3 is expressed specifically in testis and is thought to regulate transcriptional events during early sexual development. The gene encoding DMRT3 maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, and Familial dysautonomia, are both associated with chromosome 9. Notably, chromosome 9 encompasses the largest interferon family gene cluster.

Applications:

ELISA, WB, IHC

Name of antibody:

DMRT3

Immunogen:

Fusion protein of human DMRT3

Full name:

doublesex and mab-3 related transcription factor 3

Synonyms:

DMRTA3

SwissProt:

Q9NQL9

IHC positive control:

Human gastric cancer and human brain

IHC Recommend dilution:

25-100

WB Predicted band size:

51 kDa

WB Positive control:

Mouse stomach and brain tissue

WB Recommended dilution:

500-2000