兔抗CASP14多克隆抗体

Background:

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.

Applications:

ELISA, WB

Name of antibody:

CASP14

Immunogen:

Fusion protein of human CASP14

Full name:

caspase 14, apoptosis-related cysteine peptidase

SwissProt:

P31944

ELISA Recommended dilution:

2000-5000

WB Predicted band size:

28 kDa

WB Positive control:

Jurkat, A431, A549 and A375 cells

WB Recommended dilution:

500-2000