兔抗CASP12多克隆抗体

Background:

Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

CASP12

Immunogen:

Synthetic peptide of human CASP12

Full name:

caspase 12 (gene/pseudogene)

Synonyms:

CASP-12; CASP12P1

SwissProt:

Q6UXS9

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer

IHC Recommend dilution:

30-150

WB Predicted band size:

39 kDa

WB Positive control:

NIH/3T3 cell lysate

WB Recommended dilution:

500-2000