兔抗NFKBIB (Phospho-Ser23)多克隆抗体

Background:

Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further IKBA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.

Applications:

IHC

Name of antibody:

NFKBIB (Phospho-Ser23)

Immunogen:

Synthetic peptide of human NFKBIB (Phospho-Ser23)

Full name:

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta (Phospho-Ser23)

Synonyms：

IKBB; TRIP9

SwissProt:

Q15653

IHC positive control:

Human breast carcinoma

IHC Recommend dilution:

50-100