兔抗CABLES2多克隆抗体

Background:

Cables2 (Cdk5 and ABL1 enzyme substrate 2), also known as Ik3-2, is a 478 amino acid ubiquitously expressed protein that has a C-terminal cyclin box-containing domain, making it a member of the cyclin protein superfamily. A related protein, Cables, forms a trimolecular complex with Cdk5 and c-Abl in vivo, enhances apoptosis induced by overexpression of p53 and may be a tumor suppressor, due to its chromosomal loss of heterozygosity that is found in certain cancers. Cables2 shares 78% sequence similarity with Cables in the region of the cyclin box-containing domain and, in similar functionality, associates with Cdk3, Cdk5 and c-Abl. However, unlike its close relative, Cables2 also contains an N-terminal region that enhances not only p53-mediated cell death, but also p53-independent cell death. This characteristic suggests that the gene encoding Cables2 may also function as a tumor suppressor gene.

Applications:

ELISA, IHC

Name of antibody:

CABLES2

Immunogen:

Synthetic peptide of human CABLES2

Full name:

Cdk5 and Abl enzyme substrate 2

Synonyms：

ik3-2; C20orf150; dJ908M14.2

SwissProt:

Q9BTV7

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human thyroid cancer and Human brain

IHC Recommend dilution:

25-100