兔抗BCL6多克隆抗体

Background:

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

BCL6

Immunogen:

Synthetic peptide of human BCL6

Full name:

B-cell CLL/lymphoma 6

Synonyms:

BCL5; LAZ3; BCL6A; ZNF51; ZBTB27

SwissProt:

P41182

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colorectal cancer

IHC Recommend dilution:

10-50

WB Predicted band size:

79 kDa

WB Positive control:

Hela cell lysate

WB Recommended dilution:

200-1000