兔抗BAP1多克隆抗体

Background:

This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma.

Applications:

ELISA, IHC

Name of antibody:

BAP1

Immunogen:

Fusion protein of human BAP1

Full name:

BRCA1 associated protein 1

Synonyms:

UCHL2; hucep-6; HUCEP-13

SwissProt:

Q92560

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human esophagus cancer and Human breast cancer

IHC Recommend dilution:

40-200