兔抗BAIAP2L1多克隆抗体

Background:

This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation.

Applications:

ELISA, WB, IHC

Name of antibody:

BAIAP2L1

Immunogen:

Fusion protein of human BAIAP2L1

Full name:

BAI1 associated protein 2 like 1

Synonyms:

IRTKS

SwissProt:

Q9UHR4

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human esophagus cancer and human thyroid cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

57 kDa

WB Positive control:

HEPG2，Hela，A172，A549 and A431 cell lysates

WB Recommended dilution:

500-2000