兔抗APP(Phospho-Thr743/668) 多克隆抗体

Background:

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities.

Applications:

WB, IHC, IF

Name of antibody:

APP(Phospho-Thr743/668)

Immunogen:

Peptide sequence around phosphorylation site of threonine743 /668 (A-V-T(p)-P-E) derived from Human Amyloid β A4.

Full name:

amyloid beta (A4) precursor protein

Synonyms：

AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma

SwissProt:

P05067

IHC positive control:

Human brain tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

87 kDa

WB Positive control:

COS7 cells lysates

WB Recommended dilution:

500-1000

IF positive control:

Hela cells

IF Recommend dilution:

100-200