兔抗STAT2 (phospho-Tyr690)多克隆抗体

Background:

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.

Applications:

WB

Name of antibody:

STAT2 (phospho-Tyr690)

Immunogen:

Synthetic peptide of human STAT2 (phospho-Tyr690)

Full name:

signal transducer and activator of transcription 2, 113kDa (phospho-Tyr690)

Synonyms：

P113; ISGF-3; STAT113

SwissProt:

P52630

WB Predicted band size:

98 kDa

WB Positive control:

Hela cells treated with IFN-α

WB Recommended dilution:

500-1000