兔抗NR1I3多克隆抗体

Background:

This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

NR1I3

Immunogen:

Fusion protein of human NR1I3

Full name:

nuclear receptor subfamily 1 group I member 3

Synonyms:

CAR; CAR1; MB67

SwissProt:

Q14994

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human ovarian cancer and Human thyroid cancer

IHC Recommend dilution:

25-100