兔抗PSMC6多克隆抗体

Background:

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12.

Applications:

ELISA, IHC

Name of antibody:

PSMC6

Immunogen:

Fusion protein of human PSMC6

Full name:

proteasome 26S subunit, ATPase 6

Synonyms:

P44; p42; SUG2; CADP44; HEL-S-73

SwissProt:

P62333

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colorectal cancer;

IHC Recommend dilution:

20-100