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  • 兔抗SELENON多克隆抗体

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    • 品牌 : 通蔚生物
    • 目录号 : TW20907
    • 应用 : 仅供科研使用
    • 保存条件 : 低温保存
    • 货期 : 现货
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中文名称兔抗SELENON多克隆抗体   

英文名称: Anti-SELENON rabbit polyclonal antibody

别      名: selenoprotein N; RSS; CFTD; SELN; MDRS1; RSMD1; SE

相关类别: 一抗

储      存: 冷冻(-20℃)

宿      主: Rabbit

抗      原: SELENON

反应种属 Human

标记物 Unconjugate

克隆类型 rabbit polyclonal

技术规格

Background:

This gene encodes a glycoprotein that is localized in the endoplasmic reticulum. It plays an important role in cell protection against oxidative stress, and in the regulation of redox-related calcium homeostasis. Mutations in this gene are associated with early onset muscle disorders, referred to as SEPN1-related myopathy. SEPN1-related myopathy consists of 4 autosomal recessive disorders, originally thought to be separate entities: rigid spine muscular dystrophy (RSMD1), the classical form of multiminicore disease, desmin related myopathy with Mallory-body like inclusions, and congenital fiber-type disproportion (CFTD). This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A second stop-codon redefinition element (SRE) adjacent to the UGA codon has been identified in this gene (PMID:15791204). SRE is a phylogenetically conserved stem-loop structure that stimulates readthrough at the UGA codon, and augments the Sec insertion efficiency by SECIS. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2016]

Applications:

ELISA, WB, IHC

Name of antibody:

SELENON

Immunogen:

Synthetic peptide of human SELENON

Full name:

selenoprotein N

Synonyms:

RSS; CFTD; SELN; MDRS1; RSMD1; SEPN1

SwissProt:

Q9NZV5

IHC positive control:

Human thyroid cancer and Human tonsil

IHC Recommend dilution:

25-100

WB Predicted band size:

66 kDa

WB Positive control:

Human placenta tissue

WB Recommended dilution:

500-2000