兔抗ROCK2多克隆抗体

Background:

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4.

Applications:

ELISA, IHC

Name of antibody:

ROCK2

Immunogen:

Fusion protein of human ROCK2

Full name:

Rho-associated, coiled-coil containing protein kinase 2

Synonyms：

ROCK-II

SwissProt:

O75116

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human cervical cancer and human ovarian cancer

IHC Recommend dilution:

25-100