小鼠抗RAD51单克隆抗体

Background:

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene.

Applications:

WB

Name of antibody:

RAD51

Immunogen:

Fusion protein of human RAD51

Full name:

RAD51 recombinase

Synonyms:

RECA; BRCC5; FANCR; MRMV2; HRAD51; RAD51A; HsRad51; HsT16930

SwissProt:

Q06609

WB Predicted band size:

37 kDa

WB Positive control:

CHO-K1, COS7, C6, 3T3 and Hela cell lysates

WB Recommended dilution:

1000-5000