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  • 兔抗RIPK1多克隆抗体

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    • 品牌 : 通蔚生物
    • 目录号 : TW20440
    • 应用 : 仅供科研使用
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    • 货期 : 现货
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中文名称:  兔抗RIPK1多克隆抗体  

英文名称: Anti-RIPK1 rabbit polyclonal antibody

别    名 RIP; RIP1; RIP-1

抗    原 RIPK1

储    存: 冷冻(-20℃)

宿    主 Rabbit

相关类别: 一抗

反应种属 Human

标 记 物 Unconjugate

克隆类型 rabbit polyclonal

技术规格

Background:

Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.

Applications:

ELISA, WB

Name of antibody:

RIPK1

Immunogen:

Fusion protein of human RIPK1

Full name:

receptor interacting serine/threonine kinase 1

Synonyms:

RIP; RIP1; RIP-1

SwissProt:

Q13546

ELISA Recommended dilution:

5000-10000

WB Predicted band size:

76 kDa

WB Positive control:

HEPG2,Hela and K562 cell lysates

WB Recommended dilution:

500-2000